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Some people find certain types work well for them and others do not.

You may need to try more than one type to find one that works for you.

Diphenhydramine and doxylamine have anticholinergic properties that make them poor choices for older adults.

Recent studies have shown that anticholinergics may increase the risk of dementia.

Almost everyone has taken an antihistamine to treat hay fever, itching, to relieve nausea and vomiting, in tablets and syrups used to treat cough and cold symptoms, or as an aid to sleep.

Also, diphenhydramine and doxylamine — sedating antihistamines often found in over-the-counter sleep aids — aren't recommended for people who have certain conditions, such as closed-angle glaucoma, asthma, chronic obstructive pulmonary disease or severe liver disease.

The drugs of the first antihistamine generation are: promethazine, alimemazine, dexchlorpheniramine, brompheniramine, buclizine, carbinoxamine and doxylamine, are sedating and elicit a drowsiness which can be awkward.

The first-genaration antihistamines have alpha adrenolytic activity which can decrease the vasoconstrictive effect of adrenaline and noradrenaline and an antimuscarinic effect with the corresponding adverse effects.

In addition, each compound can have or not have parallel properties, antimuscarinic effects for example.

This distinction between generations must be taken with caution because a product considered as non sedative or not antimuscarinic can, in certain circumstances, large doses or particular susceptibility of the patient ,have these effects.




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